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Secretory granule exocytosis is a tightly regulated process requiring granule targeting, tethering, priming, and membrane fusion. At the heart of this process is the SNARE complex, which drives fusion through a coiled coil zippering effect mediated by the granule v SNARE protein, VAMP2, and the plasma membrane t SNAREs, SNAP 25 and syntaxin 1A. Here we demonstrate that in pancreatic… Read more →

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Special relativity has been tested sixty ways to Sunday, and there are no experimental results which contradict it (or, rather, none which are reproducible). It is incorporated into all modern theories of physics, particularly quantum electrodynamics (which is the most precisely tested scientific theory, period), and general relativity. It is also (!) mathematically consistent (self consistent, internally consistent), and reduces… Read more →

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The key is controlling Rivers in the red zone. San Diego averages only 22.2 points, 19th in the league. Tight end Antonio Gates and running back Danny Woodhead must be neutralized. Social media (SM) allow users to easily create, edit, or share content. The vast numbers of individuals that converge around sites like LinkedIn, Facebook, or Twitter embody a rich… Read more →

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Increased levels of MAO A activity were induced by STS, accompanied by increased MAO A protein and activation of the initiator of the intrinsic pathway, caspase 9, and the executioner caspase 3. MAO A mRNA levels were unaffected by STS, suggesting that changes in MAO A protein are due to post transcriptional events. Two unrelated MAO A inhibitors reduced caspase… Read more →

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