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Amongst the secreted proteins, rhoptry organelle proteins (ROPs) are essential for the parasite invasion and host cell manipulation. Even though the functions of most ROPs have been elucidated in the less virulent T. Gondii (type II), the roles of ROPs in the highly virulent type I strain remain largely un characterized. Matt Moore, making the first playoff start of his… Read more →

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The potential for siderophore mutants of Pseudomonas aeruginosa to attenuate virulence during infection, and the possibility of exploiting this for clinical ends, have attracted much discussion. This has largely been based on the results of in vitro experiments conducted in iron limited growth medium, in which siderophore mutants act as social cheats: TM increasing in frequency at the expense of… Read more →

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