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We found three novel compounds in the library that displayed unexpected sub micromolar affinity for the A3AR. These were K114 (pKi 6.43), retinoic acid p hydroxyanilide (pKi 6.13) and SU 6556 (pKi 6.17). Molecular docking of these latter three LOPAC library members provided a plausible set of binding poses within the vicinity of the established orthosteric A3AR binding pocket. Afterward,… Read more →

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Apollo 11 moonwalker Buzz Aldrin during media preview of newly opened ‘Destination Mars’ holographic experience at the Kennedy Space Center visitor complex in Florida on Sept. 18, 2016. Credit Julian LeekMeanwhile, be sure to visit the absolutely spectacular “Destination Mars” holographic exhibit before it closes on New Year’s Day 2017 because it is only showing at KSCVC.. The Maine law… Read more →

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She made two recommendations; that Public Works Advisory NSW and Local Government NSW develop guidelines for the safe design of stormwater inlets throughout the state, and that her inquest findings be sent to all NSW councils. The inquest was attended by Ryan parents, siblings and extended family, with his aunt reading a statement to the court before the coroner findings.… Read more →

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The Washington State Patrol was supporting the investigation by staffing its crime lab 24 hours a day until the samples could be is what enabled us to reach this plateau in this investigation, said sheriff office spokesman Scott Wilson. He wasn sure if the suspect and Jenise knew each other.An autopsy concluded Jenise was a homicide victim, and her… Read more →