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Here, we identify LIMD1 as a HIF 1 target gene, which mediates a previously uncharacterised, negative regulatory feedback mechanism for hypoxic HIF degradation by modulating PHD2 LIMD1 VHL complex formation. Hypoxic induction of LIMD1 expression results in increased HIF protein degradation, inhibiting HIF 1 target gene expression, tumour growth and vascularisation. Furthermore, we report that copy number variation at the… Read more →

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METHODS: Scoping review studies were screened in duplicate. Data were extracted by one researcher and checked by another. Studies were grouped by design, and then by intervention, with details summarised narratively and in tables. DESIGN, SETTING, AND PARTICIPANTS A population based, electronic medical records database from the Hong Kong Clinical Data Analysis Reporting System was used to identify 25 629… Read more →

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Item Type:Conference or Workshop contribution (Lecture)Item Status:Live ArchiveAbstractNorth Foreland Lighthouse is a grade II listed building located 1.2 miles north of Broadstairs in Kent and marks the southerly entrance to the River Thames. The original structure, dating back to 1691, consisted of a twelve metre high octagonal tower constructed from brick quoins and flint panels. Due to navigational requirements and… Read more →