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BACKGROUND: Ras association and pleckstrin homology domains 1 (RAPH1) is involved in cytoskeleton regulation and re epithelialisation in invasive carcinoma and therefore may play a key role in carcinogenesis and metastasis. We herein investigated the biological and clinical significance of RAPH1 in breast cancer using large annotated cohorts.METHODS: The clinicopathological and prognostic significance of RAPH1 was assessed at the genomic… Read more →

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And the third example drawn from the historic films of Lumire contemporaries “Mitchell and Kenyon”, whose films of Edwardian public crowds in the 1900’s provided audiences the opportunity to play and perform in front of the film camera in the knowledge they could share in the experience of watching their spectacle in the film’s screening hours later at the local… Read more →

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Can we do it? There are few practical objections, but no lack of political obstacles. Military traditionalists won’t like it, as traditionalists of another era dismissed Gen. Billy Mitchell’s outlandish ideas about air power. And I believe that that is un American,” he says. “In fact I believe that is exactly what Handmaid’s Tale is about,” he adds. “What happens… Read more →

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The first farmers in Cantabrian Spain: contribution of absolute chronology to understand an historical processFano, M. A., Cubas Morera, M. Wood, R., 7 Apr 2015Article in Quaternary International2014A historical ecology of the Ecrins (Southern French Alps): Archaeology and palaeoecology of the Mesolithic to the Medieval periodWalsh, K. This ring surrounding the Moon is caused by the refraction of Moonlight (which… Read more →

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The Generalized Problematic Internet Use Scale 2 (GPIUS2) assesses individuals’ generalized problematic Internet use (PIU) cognitions, behaviors, and negative outcomes. To date, the GPIUS2 has only been validated in English, Spanish, German, and Italian language. Therefore, the aim of this study was to validate a Portuguese version of the GPIUS2 and provide a taxonomy of the potential risk of PIU… Read more →

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Push harder. The best way to build lean muscle mass is by lifting weights or doing bodyweight exercises until you tapped out. (Just one reason why weight lifting will change your life.) “When you lift to failure the point where you physically can do it any more all your muscle fibers get the signal that they need to grow,” Baar… Read more →

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Approach, emotion regulation and reappraisal coping were predictive of self harm behaviour. Emotion regulation coping differentiated self harm ideation and enactment groups.Limitations: The cross sectional design of the study precludes the ability to make inferences regarding causality. Further, there is no agreed definition of recent TM self harm.Conclusions: Taken together, the findings suggest that functional coping dynamics may be differentially… Read more →