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FLNC turnover has been proposed to be controlled by Chaperone Assisted Selective Autophagy (CASA), a client specific and tension induced pathway that is required for muscle maintenance. Here, we have generated new C2C12 myoblast and zebrafish models of KY deficiency by CRISPR/Cas9 mutagenesis. To obtain insights into the pathogenic mechanism caused by KY deficiency, expression of the co chaperone BAG3… Read more →

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In addition to written price quotes, offers are instructed to provide: 1. Quotes shall be fully executed and returned on the Standard Form (SF) 18 and any acknowledgements of solicitation amendments on the SF 30. 2. The tower is one of the most significant examples of brutalism an architectural style popular in the 1950s and 1960s, based on crude, block… Read more →

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Officially confined to red light districts, brothels in British India were tolerated until the 1920s. Yet, by this time, prostitution reform campaigns led by Indian, imperial, and international bodies were combining the social scientific insights of sexology and hygiene with the moral condemnations of sexual slavery and human trafficking. These reformers identified the brothel as exacerbating rather than containing “corrupting… Read more →

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By controlling the freezing process of the reagent/polymer solution, large scale 3Dmacroporous gels with wide interconnected pores (up to 200 m in diameter) and large accessiblesurface area have been synthesized. For the first time, macroporous gels (of up to 400 ml bulk volume)with controlled porous structure were manufactured, with potential for scale up to much larger geldimensions. This method can… Read more →

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The experiment was conducted under laboratory conditions and involved a continuous exposure, multiple dose and time point (14, 28, and 56 days) study design. Hepatopancreas cadmium levels were measured using Flame Atomic Absorption Spectrometry and the percentage of 5 mC in samples using an ELISA based colorimetric assay. Snail death rates were also assessed. So BlackBerry is down, but is… Read more →

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The Raman measurements showed that it took several hours for the generator to reach steady state and, hence, for maximum parahydrogen production (50%) to be reached. The results obtained using Raman spectroscopy were compared to those obtained by at line low field nuclear magnetic resonance (NMR) spectroscopy. While the results were in good agreement, Raman analysis has several advantages over… Read more →

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Insurance is a critical, temporary, safety net for Americans who need help getting by, said Senator Mark Udall of Colorado. Making Coloradans pay for unemployment insurance for millionaires isn fiscally responsible and frankly, it doesn make sense. Especially at a time when money is tight and our debt is out of control, we should be looking for smart, strategic ways… Read more →

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